This project developed from an idea generated by the College of Nursing in support of their Global Disaster Nursing graduate program at University of Tennessee, Knoxville. The goal of the project is to identify, evaluate, and address the closely linked health, safety and disaster readiness needs of rural Appalachian communities in Clay County, southeastern Kentucky. This is an isolated area in dire need of professional services to strengthen wellness and disaster resilience, two requisites identified in a recent RAND Report as essential to survival in the face of disaster or major public health emergencies. The College of Nursing took the lead role in assembling a community-based Inter-professional Collaborative Practice (IPCP) consisting of disciplines that rarely work together in partnership. Our project involves three main goals: Identifying community health and safety risks; strengthening community health and wellness; and finally enhancing community disaster readiness.